Cytotoxic Effects of Simvastatin on Normal Human Osteoblasts

Statins, hydroxymethylglutaryl-coenzyme-A reductase inhibitors (HMG-Co-A), are known to reduce plasma cholesterol levels. However, the biocompatibility of Simvastatin with human bone tissue has not been studied thoroughly. The purpose this study was further investigate effectiveness different concentrations simvastatin on attachment, proliferation, toxicity, cell cycle, and apoptosis normal osteoblasts. Osteoblasts derived from alveolar chips were cultured at 1, 10, 25, 50, 75, 100 mol/L, 0 mol/L as a control. attachment evaluated 9 hours. proliferation rate cytotoxicity investigated 7, 14, 21 days. Cell cycle assessed 1 3 Statistical analysis performed using ANOVA. P-values ≤0.05 considered statistically significant. results showed that there no statistical significance (P>0.05) amongst groups in efficiency. All tested significant decrease (P<0.001) an increase (P<0.001). significantly increased time In conclusion, present findings adversely affects osteoblasts' viability by inducing apoptosis.